Fondazione Irccs Istituto Nazionale Dei Tumori, Milano

This study tests a combination of five drugs (FLIRT plus bevacizumab) as a first treatment for people with a specific genetic type of advanced colorectal cancer that has spread. The cancer must have a silenced MGMT gene and be microsatellite stable. The goal is to find the safest…

This study is for women with HER2-positive or triple-negative breast cancer whose tumors disappear completely after chemotherapy. It tests whether it is safe to skip surgery or radiation and just monitor closely instead. About 152 women will take part to see if this approach work…

This study is for men with metastatic hormone-sensitive prostate cancer that has spread to a limited number of sites. It compares standard drug therapy (apalutamide plus hormone therapy) to the same drugs plus a local treatment like radiation or surgery to the prostate. The goal …

This study looks at how the natural bacteria in your mouth might affect how well radiation therapy works for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to see if certain bacteria help control tumors or reduc…

This study looks at a rare head and neck cancer called adenoid cystic carcinoma (ACC) that has spread to other parts of the body. Researchers want to understand why some people's cancer grows slowly while others' grows quickly. They will study tumor samples and take blood tests o…

This study aims to create a more accurate way to predict duodenal cancer in people with familial adenomatous polyposis (FAP), a genetic condition that raises colon and duodenal cancer risk. Researchers will analyze endoscopy images from 300 participants to build and test two risk…

This study is for 200 people with desmoid tumors who are either being watched without treatment or receiving therapy. Researchers will analyze blood and tumor samples to understand how the immune system responds to the disease. The goal is to find biological markers that predict …

This study is creating a worldwide database to track people diagnosed with epithelioid hemangioendothelioma (EHE), a very rare type of cancer that grows in blood vessels. Researchers will collect information from 100 adult patients across Europe and the UK to learn how the diseas…

This study observes up to 50 people with a rare cancer called epithelioid haemangioendothelioma (EHE) to learn more about the disease. Researchers will collect data on symptoms, treatment history, and blood samples to find biomarkers and create lab models. The goal is to better u…

This study is building a large registry of people with rare head and neck cancers across Europe. Researchers will collect information from existing databases and doctors to understand how these cancers behave, what affects outcomes, and how well current treatments work. No new tr…

This observational study aims to see if a blood test can identify the same biological tumor types as tissue analysis in people with HPV-negative head and neck cancer. About 300 adults with locally advanced, curable cancer will give blood samples before and after treatment. Resear…