Edwards Lifesciences

This study compares two approaches for people aged 65+ with moderate aortic stenosis (a narrowed heart valve). One group gets a less invasive valve replacement (TAVR), the other gets regular monitoring. The goal is to see if early treatment reduces death and heart failure. The st…

This study tests a new device called the INNOVALVE system to fix leaky heart valves (mitral regurgitation) without open-heart surgery. It includes 65 people who are at high risk for surgery. The goal is to see if the device is safe and works well.

This study tests a new balloon-expandable heart valve (SAPIEN X4) in 200 people whose surgically replaced aortic valve is failing. Participants must be at high or greater risk for another open-heart surgery. The goal is to see if the new valve is safe and effective at controlling…

This study tests a new device called the SAPIEN M3 System to replace the mitral valve in people with severe mitral regurgitation (leaky valve) who cannot have standard surgery or other treatments. The goal is to see if the device is safe and effective at reducing death and hospit…

This study is testing a new artificial heart valve called MITRIS RESILIA in 250 Chinese patients who need their mitral valve replaced. The goal is to see how safe and well the valve works over time by measuring blood flow and any leaks. Participants must be 18 or older and willin…

This study tests a new device (PASCAL) to repair a leaky tricuspid heart valve without open-heart surgery. About 1,270 people with severe symptoms will be randomly assigned to get the device plus medical therapy or medical therapy alone. The goal is to see if the device improves …

This study is testing a new heart valve (SAPIEN 3) for people born with heart defects who have a failing valve in the pulmonary position. The valve is placed using a thin tube through a blood vessel, avoiding open-heart surgery. About 108 participants will be followed to see if t…

This study is collecting information from 500 people who need a new aortic valve to see how the INSPIRIS RESILIA valve performs in real life. Researchers will measure blood flow through the valve and check for leaks using heart ultrasounds over time. The goal is to understand how…

This study is testing a new monitoring platform in 100 adults having heart or liver transplant surgery. The goal is to collect data to help improve the device, not to treat a disease. Participants must be at least 18 years old and already scheduled for a pulmonary artery catheter…

This study looks at whether using a continuous finger cuff (VitaWave) to monitor blood pressure during outpatient surgery can detect low blood pressure (hypotension) better than the standard arm cuff that measures blood pressure every few minutes. About 188 adults having elective…