Duke University

This early-stage trial tests whether adding abatacept to standard anti-rejection drugs can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special type of stem cell transplant (omidubicel). Participants will receive the drug combination…

This study aims to see if new tests can quickly spot a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. About 3,300 people with gonorrhea will provide samples (urine, vaginal, or throat swabs) already collected for routine care. The goal is to help do…

This study tests whether inclisiran, a twice-yearly injection already approved to lower bad cholesterol, can prevent major heart and limb events in 6,000 adults who recently had artery-opening procedures. Participants receive either inclisiran or a placebo, and researchers track …

This study looks at whether yoga can improve overactive bladder symptoms in children aged 8 to 18. Participants attend a weekly yoga session for 6 weeks. Researchers will track symptom changes using questionnaires and urine tests. The goal is to find a gentle, non-drug option for…

This study tests whether injecting numbing medicine near the femoral artery can reverse high blood pressure caused by a tourniquet during ankle surgery. About 40 adults having total ankle replacement will be randomly assigned to receive the injection or a placebo. The goal is to …

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and those with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation for each participant. The goal is to u…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether this makes it harder to stop smoking. About 132 smokers, some with chronic back …

This study enrolls 100 emergency medicine physicians to test whether a simulation-based ultrasound workshop improves their diagnostic skills. Participants take a knowledge test before and after the workshop, and their hands-on skills are assessed with an objective exam. The goal …

This study is for women with breast cancer who are receiving a treatment that greatly lowers estrogen levels. Researchers want to see if this treatment changes how the heart works. They will use heart scans to measure blood flow in 90 women over two years. The goal is to learn mo…

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation training can help people with mood, anxiety, or impulse disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assigned to …

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study aims to create a nationwide registry of 400 people who have experienced drug-induced liver injury (DILI). Researchers will collect medical information and biological samples like blood and DNA to build a resource for future studies. The goal is to better understand why…