Centre Hospitalier De L'université De Montréal (chum)

This study tests whether adding a drug called fostemsavir to standard HIV treatment can lower heart disease risk. People with well-controlled HIV and at least one heart risk factor (like smoking or high blood pressure) will get either the extra drug or usual care. Researchers wil…

This study tests whether a long-term, high-dose prescription stimulant (lisdexamfetamine) can help people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 participants will receive either the drug or a placebo alongside standard care…

This study tests whether adding a high-dose stimulant medication and a rewards program (contingency management) to usual care helps adults reduce their methamphetamine use. 440 participants will be randomly assigned to one of four groups for 15 weeks. The goal is to see which com…

This study looks at whether using a heart-lung machine (ECMO) routinely during lung transplants is better than using it only when necessary. About 218 people getting a lung transplant will take part. The goal is to find out which approach reduces time in the ICU and improves reco…

This study tests whether a probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking probiotics to those on a placebo over 24 weeks. The goal is to see if probiotics can slow dise…

This study tests whether giving precise, high-dose radiation to visible cancer spots can help men with metastatic prostate cancer who are already responding to hormone therapy. About 80 participants will be randomly chosen to receive either standard care or additional radiation t…

This study looks at whether giving a blood thinner called heparin through a vein can improve the chances that a reattached finger will survive after a traumatic amputation. About 188 adults who need finger reattachment surgery will take part. Half will get the standard care plus …

This study looks at whether giving radiation to the chest after surgery can help people with stage III lung cancer who still have some cancer left after chemo and immunotherapy. About 118 adults will be randomly assigned to get either standard follow-up care or additional radiati…

This study tests a new ultrasound method to find liver cancer earlier and more accurately. About 328 adults at risk for liver cancer will get both standard and new ultrasound scans. The goal is to see if the new method can spot tumors that standard ultrasound might miss, helping …

This study tests whether a special anti-inflammatory eye drop (infliximab) can safely prevent glaucoma after a cornea transplant. About 50 adults having their first cornea transplant will use the drops after surgery. Researchers will watch for side effects and check if the drops …

This study tests whether adding a drug called aprepitant to standard anti-nausea treatments can better prevent vomiting and nausea after surgery. It involves 260 adults at high risk for these symptoms who are having outpatient surgery. The goal is to see if the combination keeps …

This study looks at whether adding a type of talk therapy called Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for people who have both alcohol use disorder and depression that hasn't improved with standard medications. The study will enroll 30 partic…

This study looks at a procedure called celiac plexus neurolysis, which uses alcohol to block pain nerves in people with pancreatic cancer. Doctors usually inject another numbing drug (bupivacaine) first, but it's not clear if that helps or might even reduce the alcohol's effect. …

This study tests whether trazodone, a common antidepressant, can help older adults (65+) sleep better. Forty participants will take either trazodone or a placebo for 28 days, then switch after a 2-week break. They will track sleep with a diary and a wrist device, and visit the cl…

This study looks at three ways to numb nerves near the spine (paravertebral block) to control pain after video-assisted lung surgery. About 90 adults having this surgery will take part. The goal is to find which method works best and why some patients still feel pain despite the …

This study compares three robotic-assisted surgery methods for lung removal to see which causes the least long-term pain. About 120 adults having lung surgery will be randomly assigned to one of three techniques. The goal is to find a way to reduce nerve damage and chronic chest …

This study tests a new ultrasound technique to measure how the lungs move and stretch in patients on breathing machines in the intensive care unit. Researchers will collect data from 10 adults with stiff lungs to see if this tool can help detect early signs of lung injury. The go…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for treatments like radiation. Researchers will use donated organ samples (not live patients) to see if the marker is easy to place, stays in place, and shows up clearly on scans…

This study follows 15,000 adults aged 45 or older who are having same-day noncardiac surgery. The goal is to find out how often heart problems or other serious events happen after these procedures and what factors increase the risk. By tracking unplanned hospital visits and admis…

This study looks at two different ways of managing fluids during liver transplant surgery. One method uses less fluid and removes some blood before re-giving it later, while the other gives more fluid to keep the heart pumping well. The goal is to see which approach helps patient…

This study aims to develop a standard method for using a new freezing catheter to take lung tissue samples and treat lung lesions. Researchers will test the technique on donated human lungs from 200 patients undergoing lung transplant surgery. The goal is to measure how well the …

This study looks at whether cannabidiol (CBD) can reduce the psychoactive effects of tetrahydrocannabinol (THC) in healthy adults who use cannabis occasionally. Researchers will give participants different combinations of CBD and THC and measure how they feel and behave. The goal…

This study looks at whether a specific method of removing the breathing tube after abdominal surgery can prevent lung problems like collapsed lungs or pneumonia. It involves 270 adults at moderate or high risk for these complications. The goal is to find the best extubation techn…

This study uses donated lungs to test better ways to find and seal air leaks that can happen during lung surgery. Researchers will try a special bio-adhesive to close leaks and measure how well it works. The goal is to reduce complications and shorten hospital stays for people wh…

This study tests a new automated system to help head and neck cancer patients get their follow-up radiation therapy sooner after surgery. Delays can hurt outcomes, so the system uses alerts and risk predictions to speed up appointments. About 85 adults with oral or larynx cancer …