Basilea Pharmaceutica

This study tested an experimental drug called APX001 in 9 adults with bloodstream or deep-organ infections caused by the drug-resistant fungus Candida auris. Participants had few or no other treatment options. The goal was to see if the drug could clear the infection and keep pat…

This early-stage study tested a new oral drug called APX001 in 46 healthy adults to see if it is safe and how the body processes it. The goal was to gather information for future development of a treatment for fungal infections. Participants received either the drug or a placebo,…

This study tested a new antifungal drug called APX001 in 21 adults with a serious bloodstream fungal infection (candidemia), including cases where standard treatments might not work. Participants received the drug for up to 14 days, with possible extra treatment afterward. The go…

This study looked at how the body handles a single dose of the antifungal drug fosmanogepix in 28 adults with different levels of liver function. Researchers measured drug levels in the blood and checked for side effects. The goal is to understand if liver problems change how the…

This early-stage study tested the safety and tolerability of a new antifungal drug called APX001 in about 80 healthy adults. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The goal was to gather initial safety…

This study looked at how safe two experimental antibiotics, VNRX-7145 and ceftibuten, are when given alone or together. It involved 53 healthy adults aged 18 to 55. The goal was to measure how the drugs move through the body and check for side effects, not to treat any disease.

This study tested the safety of a new drug called VNRX-5024 in 36 healthy adults aged 18 to 55. Participants received either the drug or a placebo, with doses increasing over time. The main goal was to check for side effects and see how the drug moves through the body. No treatme…

This study looked at how taking a new antibiotic (ceftibuten/VNRX-7145) with or without food changes the amount of drug in the blood. It involved 24 healthy adults aged 18-65. The goal was to understand the best way to take the medicine for future use.

This early-stage study tested the safety of a new drug called VNRX-7145 in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the drug moves through the body and if it causes any side effects. The goal was not to …

This study looked at how a single antibiotic (ceftobiprole) changes the way the body processes a cholesterol-lowering drug (pitavastatin) and a natural substance (coproporphyrin I). Twelve healthy adults took pitavastatin alone and then with ceftobiprole to measure drug levels an…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the body and into the lungs. Thirty-four healthy adults took the drugs and had one bronchoscopy to collect lung fluid samples. The goal was to measure drug levels, not to treat any disease.

This early-stage study looked at how the experimental drug fosmanogepix behaves in the bodies of 54 healthy Chinese adults. Participants received either a single dose or multiple doses of the drug, given by IV or as a pill, to measure safety and how the drug is processed. The goa…

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the body in 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and ch…