Australian And New Zealand Intensive Care Research Centre

This study tests whether giving sodium bicarbonate (a common acid neutralizer) to adults in the intensive care unit with metabolic acidosis and shock can reduce the risk of death, kidney failure, or lasting kidney damage within 30 days. About 500 participants receive either the b…

This study looks at 1000 adults with septic shock (a severe infection causing very low blood pressure) in emergency departments. It compares two approaches: giving less IV fluid and starting blood-pressure-raising drugs early, versus giving more fluid first and adding drugs later…