Aids Malignancy Consortium

This early study tests adding daratumumab, an antibody that targets a protein on cancer cells, to standard chemotherapy for people with newly diagnosed plasmablastic lymphoma, a rare and fast-growing cancer. The trial includes up to 15 participants, with or without HIV. The main …

This study tests a drug called ixazomib in people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking enzymes that cancer cells need to grow. Researchers want to see if it can shrink tumors and will monitor side effects. About 41 adults with measurable skin les…

This study tests a CAR-T cell therapy (axicabtagene ciloleucel) in 20 HIV-positive adults whose aggressive B-cell lymphoma has come back or stopped responding to standard treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells. The …

This study looks at whether surgically removing a type of eye tumor called ocular surface squamous neoplasia (OSSN) is practical for people living with HIV in Sub-Saharan Africa. About 84 participants will have the tumor cut out and be followed for a year to see if the procedure …

This study is testing whether a smartphone app designed for people with HIV can help them quit smoking when combined with a lung cancer screening CT scan. About 100 participants will use the app and get a low-dose CT scan. The goal is to see if this approach is practical and help…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…