Adventhealth Translational Research Institute

This small pilot study looks at whether doing 20-30 minutes of moderate exercise right before immunotherapy can help the treatment work better for people with certain skin cancers (melanoma, squamous cell carcinoma, and Merkel cell carcinoma). The study includes 12 adults schedul…

This study looks for new biological markers (biomarkers) in the blood that could help doctors diagnose type 1 diabetes earlier and track how the disease progresses. Researchers are comparing teens newly diagnosed with type 1 diabetes to healthy teens without the condition. The go…

This early-phase study aims to understand how well people with obesity tolerate glucagon, a hormone that may help with weight loss. About 20 healthy obese adults will receive increasing doses of glucagon through an IV, and researchers will measure when they start feeling nauseous…

This study looks for early signs of type 1 diabetes and celiac disease in 115 children and adults who are at higher risk but may not have easy access to healthcare. Participants provide a blood sample to test for specific autoantibodies. The goal is to improve how we screen for t…

This study looks at why some people store fat around their belly (apple shape) while others store it around their hips and thighs (pear shape). Researchers will take small fat samples from 27 healthy adults and study the epigenetic marks—chemical tags that control how genes work—…

This study looks at how aerobic and resistance exercise can leave a lasting imprint on muscle cells, helping them work better over time. Researchers will take muscle samples from 179 adults before and after exercise training to study changes in metabolism and gene activity. The g…

This study looks at how giving glucagon (a hormone) for 72 hours changes the amount of energy the body uses in healthy, non-diabetic adults with obesity. Researchers compare glucagon to a placebo to see if it boosts energy expenditure. The goal is to learn more about how glucagon…

This study looks at how a low-carb diet combined with an SGLT2 inhibitor (a diabetes drug) changes ketone levels in healthy adults. Nine volunteers aged 18-60 with a stable weight will be monitored. The goal is to understand if this combination safely produces moderate ketosis, n…

This study looks at how exercise affects signals from muscles that help burn fat. Researchers will compare obese, lean, and athletic adults aged 18-40. They measure muscle energy use and proteins in blood and tissue samples. No treatment is given; the goal is to learn more about …

This study aims to discover new biological markers (called microRNAs) in the blood that could help identify and understand Adult Onset Autoimmune Diabetes. Researchers will collect blood samples from 25 adults with type 1 diabetes to look for changes in these markers. The goal is…

This study looks at why some people with type 2 diabetes don't get the usual benefits from exercise. Researchers will measure how well cells make energy before and after exercise. The goal is to find factors that cause this 'exercise resistance' in about 84 adults aged 30 to 65.

This study looks at how exercise training changes the way muscles and fat tissue respond to insulin in people with type 2 diabetes. Researchers will use special scans and small tissue samples to measure glucose uptake and energy production. The goal is to better understand the be…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who have diabetes and those who don't. Researchers will use scans to measure organ size and other changes in 35 adults who had COVID-19. The goal is to learn more about long-term effect…