X-linked chronic granulomatous disease
Clinical trials for X-linked chronic granulomatous disease explained in plain language.
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Gene fix trial aims to tame rare immune disease
Disease control By invitation onlyThis study tests a gene therapy for people with X-linked chronic granulomatous disease (X-CGD), a genetic condition that weakens the immune system and leads to severe infections. Researchers take the patient's own stem cells, add a working copy of the faulty gene, and return the …
Matched conditions: X-LINKED CHRONIC GRANULOMATOUS DISEASE
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Gene therapy aims to fix immune system in rare disease
Disease control OngoingThis study tests a one-time gene therapy called EN-374 for people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder that causes severe infections. The treatment uses a modified virus to deliver a working gene to blood stem cells, aiming to restore the ab…
Matched conditions: X-LINKED CHRONIC GRANULOMATOUS DISEASE
Phase 1/2 • Sponsor: Ensoma • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Gene therapy hope for rare immune disease fails to launch
Disease control CancelledThis trial aimed to test a gene therapy for X-linked chronic granulomatous disease, a condition where the immune system cannot fight certain infections. The treatment involved taking the patient's own stem cells, adding a working copy of the defective gene, and returning them to …
Matched conditions: X-LINKED CHRONIC GRANULOMATOUS DISEASE
Phase 1/2 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC