UROTHELIAL CARCINOMA BLADDER

This early-stage trial tests a personalized cell therapy called 4SCAR-T for people with advanced bladder cancer that has spread and has no standard treatments left. About 20 participants will receive specially engineered immune cells designed to attack their cancer. The study aim…

This study tests a decision tool to see if it can safely identify women with bladder cancer who can keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder along with the uterus, ovaries, and part of the vagina, which can cau…

This early-stage study tests whether giving immunotherapy at the same time as radiation is safe for people with bladder cancer who have already had surgery to remove their bladder. The trial will enroll 10 participants and closely monitor for serious side effects in the pelvic ar…

This early-phase trial tests a new treatment called VET3-TGI, a virus designed to infect and kill cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The main go…

This early-stage trial is testing a new drug called belzupacap sarotalocan (AU-011) for people with a type of bladder cancer that hasn't spread into the muscle layer. The drug is injected directly into the tumor, sometimes with a laser, to see if it's safe and possible to do. Abo…

This early-stage study tests a new drug that delivers radiation directly to cancer cells. It is for people with advanced solid tumors like bladder, breast, lung, or cervical cancer that have not responded to prior treatments. The main goals are to find the safest dose and see if …

This study tests a new version of BCG treatment (VERITY-BCG) for people with intermediate or high-risk non-muscle invasive bladder cancer who have not received BCG before. The goal is to see if the new treatment is as good as the standard BCG at preventing the cancer from returni…

This study tests a combination of two cancer drugs, enfortumab vedotin and pembrolizumab, in 20 people with high-grade upper tract urothelial cancer (a rare cancer of the kidney and ureter). Participants are those who cannot or choose not to have standard surgery to remove the ki…

This study is testing a new urine test called Bladder EpiCheck to see how well it finds bladder cancer in people aged 45 and older who have blood in their urine. About 800 participants will provide a urine sample and then undergo standard cystoscopy (a camera exam of the bladder)…

This study looks at whether walking 8,000 to 10,000 steps each day for four weeks before bladder cancer removal surgery can lower the chance of problems after the operation. About 146 adults with bladder cancer will take part. Half will be asked to walk more using a step counter,…