UROGENITAL NEOPLASMS

This early-phase study tests two experimental drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination is safe and helps the immune system f…

This study tests the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side ef…

This study tests whether giving a combination of chemotherapy (carboplatin/paclitaxel) and an immunotherapy drug (pembrolizumab) before surgery can completely eliminate cancer in men with advanced penile cancer that has spread to lymph nodes. About 27 participants will receive th…

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can help some patients with stage II-IIIa bladder cancer avoid bladder removal. About 90 participants will receive either one or both drugs, and doctors will check if the cancer disa…

This study tests a new drug called 177Lu-rhPSMA-10.1 in men with metastatic castrate-resistant prostate cancer, a type of prostate cancer that has spread and no longer responds to hormone therapy. The drug delivers radiation directly to cancer cells. The study has two phases: Pha…

This study tests a new drug called pocenbrodib, either alone or with other treatments, in people with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The goal is to find the safest dose and see if it can shrink tumors or lower PSA levels. A…

This study aims to see if a new imaging agent called [18F]RCCB6 can improve PET/CT scans for diagnosing kidney cancer, especially the most common type (clear cell renal cell carcinoma). About 300 adults with confirmed or suspected kidney cancer will receive the agent and undergo …

This study tracks 1,100 adults with common and rare urinary tract cancers (like bladder, kidney, or testicular cancer) over their lifetime. Researchers collect medical records, blood, urine, and tumor samples to understand how these cancers behave and respond to treatment. The go…

This study is testing a new lab test called SPHERTEST to see if it can predict whether immunotherapy will work for people with advanced bladder cancer. Researchers will take blood and tumor samples from 32 patients to build a 3D cell model. The goal is to find a way to personaliz…