UROGENITAL NEOPLASMS

This early-stage study is testing whether two new immunotherapy drugs, M7824 and PDS01ADC, can help the body's immune system fight advanced bladder, kidney, and related cancers that have spread. Researchers want to see if adding a precise, high-dose radiation treatment (SBRT) mak…

This study is testing a treatment plan for men with advanced penile cancer that has spread to nearby lymph nodes. Participants receive a combination of chemotherapy and immunotherapy drugs before surgery, followed by more immunotherapy after surgery. The main goal is to see if th…

This study is testing a new drug called Pocenbrodib to see if it is safe and can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. Researchers will give Pocenbrodib alone or combined with other cancer drugs to about …

This study is testing whether giving two immunotherapy drugs before surgery can shrink bladder tumors enough to avoid removing the bladder entirely. The trial will enroll 90 adults with muscle-invasive bladder cancer who are not receiving standard chemotherapy. Researchers will c…

This study is observing how well the drug vorolanib works and how safe it is for patients with advanced kidney cancer that has spread or cannot be removed by surgery. It involves 39 adults who are receiving vorolanib as their second treatment option. Researchers will track how lo…

This study is testing a new radioactive drug called lutetium (177Lu) rhPSMA-10.1 for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The goal is to find a safe and effective dose that can shrink tumors by delivering rad…

This study is testing a new type of PET/CT scan that uses a special tracer called [18F]RCCB6. The goal is to see if this scan can more accurately detect and diagnose kidney cancer, especially a common type called clear cell renal cell carcinoma. Researchers will enroll 300 partic…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…

This study is testing a new laboratory method called SPHERTEST to see if it can predict whether a patient's advanced bladder cancer will respond to immunotherapy drugs. Researchers will grow tiny 3D tumor models using cells from 32 patients and see how they react to immunotherapy…