UPPER TRACT UROTHELIAL CARCINOMA

This study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor to target and kill cancer cells. Up to 42 adults will receive the cells …

This study looks at whether removing nearby lymph nodes during standard surgery for high-risk upper tract cancer helps patients live longer without the cancer coming back. About 150 adults will be randomly assigned to get either the standard surgery alone or with lymph node remov…

This study tests whether giving the immunotherapy drug avelumab after standard chemotherapy can help prevent upper tract urothelial cancer from coming back. About 48 adults who have already completed chemotherapy and show no signs of cancer will receive avelumab as a maintenance …

This study is testing whether a drug called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during a procedure called ureteroscopy. About 10 adults with known or suspected upper tract urothelial cancer will take 5-ALA before surgery…

This study tests whether a personalized home exercise program before bladder cancer surgery can improve physical function and recovery. About 128 adults scheduled for bladder or upper tract surgery will either receive the exercise program plus standard care, or standard care alon…

This pilot study tests whether a flexible scope can be used under local anesthesia (awake) to monitor for cancer recurrence in the upper urinary tract. Ten adults who had kidney-sparing surgery for upper tract urothelial carcinoma will undergo the procedure in an outpatient setti…