Unresectable or metastatic melanoma
Clinical trials for Unresectable or metastatic melanoma explained in plain language.
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Can a Two-Drug combo outsmart advanced melanoma?
Disease control Not yet recruitingResearchers are testing whether adding the chemotherapy drug irinotecan to the immunotherapy pembrolizumab helps people with metastatic or recurrent melanoma that cannot be removed by surgery. The trial enrolls adults whose cancer has returned at least six months after adjuvant p…
Matched conditions: UNRESECTABLE OR METASTATIC MELANOMA
Phase 1/2 • Sponsor: Yonsei University • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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PET scans may help supercharge immune cell therapy against melanoma
Disease control Not yet recruitingThis pilot study explores whether a special PET/CT scan that tracks CD8 immune cells can help select the best tumors for harvesting immune cells (TILs) to treat stage IV melanoma. Participants receive the TIL therapy lifileucel (AMTAGVI) after a chemotherapy regimen. The goal is …
Matched conditions: UNRESECTABLE OR METASTATIC MELANOMA
Early phase 1 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New hope for immunotherapy side effects: blood filtering may replace steroids
Disease control Not yet recruitingThis study tests a treatment called extracorporeal photopheresis (ECP) for people with advanced melanoma who develop severe colitis or hepatitis from immunotherapy. ECP filters a patient's blood, treats it with a light-activated drug, and returns it to the body. The trial compare…
Matched conditions: UNRESECTABLE OR METASTATIC MELANOMA
Phase 2 • Sponsor: Therakos LLC • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC