Transfusion-dependent beta-thalassemia
Clinical trials for Transfusion-dependent beta-thalassemia explained in plain language.
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Could two old drugs free thalassemia patients from lifelong transfusions?
Disease control CompletedThis phase 2 trial tested whether combining thalidomide and hydroxyurea can reduce the need for blood transfusions in people with transfusion-dependent beta thalassemia. The study enrolled 100 patients over age 2 in Pakistan, where thalassemia is common and life expectancy is low…
Matched conditions: TRANSFUSION-DEPENDENT BETA-THALASSEMIA
Phase 2 • Sponsor: Pakistan Blood and Marrow Transplant (PBMT) Group • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Can metformin or hydroxyurea cut transfusions for thalassemia patients?
Disease control CompletedThis completed Phase 4 trial tested two drugs—hydroxyurea and metformin—in 96 people with transfusion-dependent beta-thalassemia. Participants took one of the two drugs for a year. Researchers measured changes in fetal hemoglobin levels and how often blood transfusions were neede…
Matched conditions: TRANSFUSION-DEPENDENT BETA-THALASSEMIA
Phase 4 • Sponsor: Bahria University • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Weekly shot could replace daily insulin for thalassemia kids with diabetes
Disease control CompletedThis study tested a once-weekly injection called dulaglutide (a GLP-1 drug) against daily insulin in 80 children aged 10-18 with transfusion-dependent thalassemia and diabetes. The goal was to see if the weekly shot could control blood sugar just as well or better than insulin ov…
Matched conditions: TRANSFUSION-DEPENDENT BETA-THALASSEMIA
Phase 2 • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC