THYROID NODULE

This study tests whether Prunella oral liquid, a herbal remedy, can safely shrink benign thyroid nodules. About 234 adults with solid nodules (1-3 cm) will receive either the herbal liquid or a placebo for 9 months. The main goal is to see if nodule volume decreases, with follow-…

This study tests a new device that uses electrical pulses to shrink benign (non-cancerous) thyroid nodules without surgery. About 100 adults with symptomatic nodules will receive the treatment and be followed for up to a year. The goal is to reduce nodule size and improve symptom…

This study looks at whether closely monitoring small thyroid nodules (under 2 cm) with regular ultrasounds is a safe and effective alternative to immediate surgery. The goal is to avoid unnecessary operations and the need for lifelong thyroid medication. Researchers will follow 1…

This study looks at whether contrast-enhanced ultrasound (a special type of ultrasound that shows blood flow) can help doctors more accurately tell if a thyroid nodule is cancerous. Researchers will compare two ways of combining standard ultrasound with this special ultrasound to…

This study aims to develop a computer model that combines ultrasound images and cell slide pictures to more accurately predict whether a thyroid nodule is cancerous. It includes 396 people whose initial tests were unclear (called Bethesda III). The goal is to reduce unnecessary s…

This study tests a minimally invasive procedure called radiofrequency ablation (RFA) for LatinX adults with benign thyroid nodules that cause discomfort or cosmetic issues. Instead of surgery, a thin needle uses heat to shrink the nodule. The goal is to see if RFA is safe and eff…

This study reviews 600 patients' records over 10 years to find out why some people develop low calcium levels after thyroid removal. Low calcium is a common complication, affecting up to half of patients. The goal is to identify risk factors so doctors can better predict, prevent…

This study is testing a decision aid for people with small thyroid nodules that are either cancerous or have a chance of being cancerous. The goal is to see if the tool helps patients choose a treatment that aligns with their personal values. Participants will fill out surveys be…

This study is testing a new type of ultrasound called multiparametric ultrasound (mpUS) to see if it can give doctors more detailed information about tissue in the pancreas and thyroid. Researchers will compare mpUS images to standard ultrasound and other tests. The goal is to le…

This study aims to improve and test a prediction model that helps doctors know how difficult a thyroid surgery through the mouth or chin will be. Researchers will enroll 300 people with thyroid cancer or benign nodules. The goal is to make surgery safer and create better training…

This study aims to create and test a new scoring system (RTAS) to evaluate how well surgeons perform robotic thyroidectomy. Researchers will enroll 200 people with thyroid cancer or benign thyroid nodules who are having robotic surgery. The goal is to improve surgical training an…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) or active monitoring with regular ultrasounds. The goal is to see if monitoring causes less anxiety and maintains quality of life. Twenty adults…