THYROID NEOPLASMS

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study tests a therapy called EMDR to help people with advanced thyroid cancer who also have PTSD. The therapy combines group and individual sessions to reduce stress and trauma symptoms. Researchers will enroll 25 participants to see if this approach is helpful and practical…

This study tests a website designed to help thyroid cancer patients manage symptoms and improve quality of life after radioactive iodine (RAI) treatment. About 88 adults who had RAI in the last three years will use either the new website or a standard information site for four we…

This study aims to collect tumor and healthy tissue samples from up to 2,415 people scheduled for surgery or biopsy for endocrine tumors (thyroid, parathyroid, adrenal, pancreas, or neuroendocrine). Researchers will analyze the samples to find genetic and molecular differences th…

This study is watching 120 people with advanced thyroid cancer to see how their tumors respond to treatment given before surgery. Researchers will measure changes in tumor size on scans, check cancer markers in the blood, and look at removed tissue under a microscope. The goal is…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) or active monitoring with regular ultrasounds. The goal is to see if monitoring causes less anxiety and maintains quality of life. Twenty adults…

This study aims to find the genes that cause pheochromocytoma and paraganglioma, rare tumors of the nervous system. Researchers will analyze DNA from up to 2,000 patients and their family members to link specific genetic changes to tumor development. The goal is to improve geneti…