Substance use disorder

This pilot trial tests whether a personalized brain stimulation technique can help people with methamphetamine use disorder. The approach uses closed-loop theta-burst stimulation, which delivers magnetic pulses to a specific brain region in real time, triggered by the person's ow…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests a program that provides overdose education and naloxone (a drug that reverses opioid overdoses) to homeless veterans at risk. The program is being rolled out at VA sites that serve veterans in supportive housing. Researchers will measure how well sites adopt the …

People hospitalized after a traumatic injury often face post-traumatic stress, depression, and substance use problems. This study tests a program called Trauma Resilience and Recovery Program Portal 2.0, which adds bedside screening, education, text-message check-ins, and follow-…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This clinical trial is testing a medical device that has not yet been approved by the U.S. FDA. Because the trial details are withheld, the exact purpose, participants, and approach are not publicly known. The study is likely gathering early information on the device's safety and…

This study looks at 125 hospitalized adults who have both a mental disorder and a substance use problem (dual diagnosis). Researchers want to see if things like social support and coping skills are linked to better treatment adherence and daily functioning. The goal is to find pr…