STAGE IV OVARIAN CANCER AJCC V8

This phase II trial tests a drug called PLX038 in 43 people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum-based chemotherapy. The drug aims to shrink tumors by blocking enzymes that help cancer cells grow. Researchers will measure how …

This early-stage trial is testing the drug talazoparib together with radiation therapy for people whose gynecologic cancer (ovarian, endometrial, cervical, or related cancers) has come back. The main goal is to find the safest dose and see how well the combination works at shrink…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers) that haven't responded to standard treatments. The main goal is to find the safest dose and under…

This phase 2 trial is testing the drug talazoparib in people with advanced solid tumors that have specific mutations in DNA repair genes. Talazoparib works by blocking a protein called PARP, which cancer cells use to fix their damaged DNA, leading to cancer cell death. The study …

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions) and the other will have standard open surgery…

This early-stage trial is testing the safety of a new method called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a minimally invasive surgery. The study includes adults with ovarian, uterine, appendix, stomach, or colorectal canc…

This study tests the safety of giving heated chemotherapy directly into the abdomen during surgery for advanced ovarian, fallopian tube, or peritoneal cancer. About 45 participants will receive either heated chemo during surgery or standard chemo before surgery. The goal is to se…

This early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to find …

This study is testing whether DNA from a uterine wash and proteins in the blood can help detect ovarian cancer earlier. Researchers will collect samples from 250 women before surgery for suspected ovarian cancer or as a preventive measure. The goal is to see if these tests can te…

This study tests whether a personalized, automated physical activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. Researchers will compare the program to standard exercise advice in 120 particip…

This study tests whether taking probiotics (healthy bacteria supplements) can improve gut and vaginal health in 161 people with advanced or recurrent ovarian cancer who are receiving platinum chemotherapy. Participants will take either probiotic pills or a placebo, and researcher…