STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Clinical trials for STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7 explained in plain language.
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Triple threat: new combo tackles Hard-to-Treat melanoma
Disease control OngoingThis phase II trial tests two different three-drug combinations in people with advanced BRAF-mutated melanoma that has spread or can't be removed surgically. One group gets nivolumab (immunotherapy) plus trametinib and dabrafenib (targeted drugs); the other gets nivolumab plus en…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 23, 2026 21:16 UTC
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Immune cocktail shows promise in Tough-to-Treat melanoma
Disease control OngoingThis phase II trial tests whether adding GM-CSF (a protein that boosts immune cell production) to the immunotherapy drug ipilimumab helps people with advanced melanoma live longer. About 245 patients with stage III or IV melanoma that cannot be removed by surgery are randomly ass…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 23, 2026 12:09 UTC
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Can breathing in a immune booster fight lung tumors?
Disease control OngoingThis study tests an inhaled form of interleukin-2 (IL-2), a protein that helps the immune system fight cancer. It is for people whose cancer has spread to the lungs from melanoma, sarcoma, or kidney cancer. The goal is to find the best dose and see if it can shrink lung tumors wi…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 23, 2026 12:08 UTC
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Could a malaria drug help fight cancer? early trial tests new combo
Disease control OngoingThis early-phase trial tests two drugs together—MK-2206 and hydroxychloroquine—in people with advanced solid tumors, melanoma, kidney, or prostate cancer. The goal is to find the safest dose and see how the combination affects cancer cell growth. About 62 participants will take b…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 23, 2026 12:01 UTC
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Could a drug holiday work just as well for melanoma?
Disease control OngoingThis phase II trial tests whether taking targeted drugs (dabrafenib and trametinib) with planned breaks works as well as taking them every day for people with advanced melanoma that has a BRAF mutation. About 280 participants will be randomly assigned to either continuous or inte…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 23, 2026 12:00 UTC
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Can a Cell-Blocking drug stop advanced melanoma?
Disease control OngoingThis phase II trial is testing a drug called dinaciclib in 72 people with stage IV melanoma that has spread. The drug works by blocking certain enzymes that cancer cells need to grow. Researchers are looking at how well it controls the disease and what side effects occur.
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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New combo therapy for advanced melanoma enters early human testing
Disease control OngoingThis early-phase trial tests the safety and best dose of combining two drugs—pembrolizumab (Keytruda) and ibrutinib (Imbruvica)—in 20 people with advanced melanoma that cannot be removed by surgery. Pembrolizumab helps the immune system attack cancer cells, while ibrutinib blocks…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 23, 2026 11:56 UTC
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Supercharged T-Cells take on melanoma in early trial
Disease control OngoingThis early-phase trial tests whether giving patients with advanced melanoma immune cells that have been genetically modified to resist tumor-suppressing signals can help fight the cancer. The modified T-cells are given along with high-dose Interleukin-2, a drug that boosts immune…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 23, 2026 11:56 UTC
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New combo therapy offers hope for melanoma patients who failed standard treatment
Disease control OngoingThis phase 2 trial studies a combination of two immunotherapy drugs—talimogene laherparepvec (T-VEC) and pembrolizumab—in 43 adults with advanced melanoma that has worsened despite prior anti-PD1/L1 therapy. T-VEC is a modified virus that infects and kills cancer cells while also…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 22, 2026 12:07 UTC
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New drug combo targets Hard-to-Treat cancers in early trial
Disease control OngoingThis early-phase trial tested the safety and best dose of two drugs—riluzole and sorafenib—given together to people with advanced solid tumors or melanoma that had spread and stopped responding to standard treatments. The goal was to find the highest safe dose and see if the comb…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 17, 2026 12:03 UTC
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New hope for tough melanoma: drug targets Cancer's growth signals
Disease control OngoingThis study tests a drug called ibrutinib in people with stage IV melanoma (skin cancer that has spread) that did not get better with other treatments. Ibrutinib works by blocking certain enzymes that cancer cells need to grow. The main goal is to see if the drug can shrink tumors…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 15, 2026 19:07 UTC
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Double immune attack: new combo therapy shows promise for tough melanoma
Disease control OngoingThis study tested two different doses of the immunotherapy drug ipilimumab, either alone or combined with high-dose interferon, in 88 people with advanced melanoma that could not be surgically removed. The goal was to see if the combination could delay cancer growth better than i…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 15, 2026 19:04 UTC
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Major trial tests immune drug against standard therapy for High-Risk melanoma
Disease control OngoingThis large phase 3 study tested whether the immunotherapy drug ipilimumab works better than high-dose interferon alfa-2b at preventing melanoma from coming back after surgery. Over 1,600 patients with high-risk stage III or IV melanoma that had been completely removed took part. …
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 12, 2026 12:07 UTC
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New drug combo targets tumor blood supply and growth
Disease control OngoingThis early-phase study tested two experimental drugs, cediranib and selumetinib, in 19 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and check for side effects. The drugs work by blocking blood vessel gr…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 12, 2026 12:04 UTC
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Triple therapy may boost survival in advanced melanoma
Disease control OngoingThis study tests whether adding a drug called sargramostim to two immunotherapy drugs (nivolumab and ipilimumab) helps people with advanced melanoma that cannot be removed by surgery. About 600 adults with stage III or IV melanoma will receive either the two-drug or three-drug co…
Matched conditions: STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7
Phase: PHASE2, PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 09, 2026 12:09 UTC