STAGE IIIB BREAST CANCER AJCC V7

This early-stage trial tests a gel form of the drug endoxifen on the breast skin of 32 women scheduled for mastectomy. The goal is to see if the gel is safe and can reduce breast cancer risk. Participants apply the gel or a placebo daily for up to 4 weeks before surgery, and rese…

This phase 2 study tests the drug pembrolizumab in 21 people with advanced solid tumors that have specific gene changes (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or stop the cancer from growing. This is not a cure, but a way to control the disease.

This early-stage trial tested the safety and best dose of two drugs—cyclophosphamide and veliparib—given together to people with HER2-negative breast cancer that has spread or cannot be removed by surgery. The goal was to find the right dose for future studies and to see if the c…

This study tests whether a newer drug, z-endoxifen, works better than the standard tamoxifen for postmenopausal women with a certain type of advanced breast cancer (ER+/HER2-). About 81 women whose cancer has spread despite prior hormone therapy will be randomly assigned to one o…

This study tested a combination of two drugs, cediranib and olaparib, in 122 people with advanced or spreading solid tumors, including certain breast, lung, and pancreatic cancers. The goal was to see if the combo could shrink tumors by blocking enzymes that help cancer grow and …

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce chronic pain in women who had breast cancer surgery. About 111 women with stage I-III breast cancer who have pain lasting at least 3 months after treatment will be randomly …