STAGE IIIA BREAST CANCER AJCC V7

This study tests whether a newer drug, Z-Endoxifen, works better than the standard drug tamoxifen for postmenopausal women with a certain type of advanced breast cancer (ER+/HER2-). The cancer has spread or come back despite prior hormone therapy. About 81 women will be randomly …

This study tests the drug pembrolizumab in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. Pembrolizumab is a type of immunotherapy that helps the immune system…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced or inoperable solid tumors, including certain breast, lung, and pancreatic cancers. The goal is to see if the combo can shrink tumors or slow their growth by blocking enzymes that cancer …

This study compares a 3-week radiation schedule to the usual 5-week schedule for breast cancer patients who need radiation to the lymph nodes near the breast. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back, while also reduci…

This study tests whether an integrative oncology program—including diet advice, physical activity, stress management, and social support—can improve quality of life and long-term outcomes for women with stage II or III breast cancer undergoing radiation therapy. About 110 partici…

This study tests whether a type of acupuncture using mild electrical pulses can reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women with persistent pain for at least 3 months after surgery will receive either real acupuncture, a…