STAGE III PROSTATE CANCER AJCC V8

This study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for men whose prostate cancer has returned or spread to a few spots after surgery. About 118 participants will receive o…

This study tests whether adding the drug apalutamide to usual hormone therapy and radiation can keep prostate cancer from spreading in men whose cancer reached lymph nodes after prostate removal surgery. About 586 men will be randomly assigned to get either standard treatment alo…

This study tests a precise type of radiation called proton therapy for men with high-risk prostate cancer that has spread to lymph nodes. The goal is to see if targeting the tumor and nearby lymph nodes causes fewer bowel and bladder side effects than standard radiation. About 30…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This study compares a new, shorter radiation treatment (5 sessions over 2 weeks) to the standard longer treatment (20 to 45 sessions over 4 to 9 weeks) for men with high-risk prostate cancer. The goal is to see if the shorter course works just as well at preventing the cancer fro…

This study tests whether taking high doses of vitamin D can help prevent bone loss in men aged 50 and older who are receiving hormone therapy (ADT) for prostate cancer. About 240 participants will receive either high-dose vitamin D or a placebo for one year. The goal is to see if…

This study compares two hormone therapy combinations for men with advanced prostate cancer who are also getting radiation. The goal is to see which combination causes less damage to the heart and blood vessels. Participants will be randomly assigned to receive either leuprolide o…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can better control the cancer. About 200 participants will receive either hormone therapy alone or with niraparib. T…

This study tests whether a special PET/MRI scan can accurately predict if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer will get the scan before surgery to remove the prostate. The goal is to see if the scan can identify who truly n…

This study tests whether taking a hormone-blocking drug (relugolix) for a few days before a PSMA PET/CT scan can make prostate cancer cells more visible. The goal is to improve detection of cancer that has spread to lymph nodes in men with high-risk prostate cancer. About 30 part…

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. About 75 men with prostate cancer that has spread will take one of these medications. The goal is to see which treatment causes few…

This study tests whether a newer, shorter radiation method (2 sessions) causes fewer side effects than the standard approach (5 sessions) for men with localized prostate cancer. About 144 participants will receive either the shorter or standard treatment, and their quality of lif…

This study looks at whether giving cancer therapy at home instead of in a clinic can improve the experience for Black men with advanced prostate cancer. About 38 participants will try both home and clinic treatments to compare safety, side effects, and satisfaction. The goal is t…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are on hormone therapy. About 210 men will either start light therapy right away or wait a few months. The goal is to help patients feel …

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many Afri…