Severe combined immunodeficiency
Clinical trials for Severe combined immunodeficiency explained in plain language.
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Can a Precision-Engineered transplant rebuild immunity in babies born without it?
Cure OngoingInfants with severe combined immunodeficiency (SCID) lack working immune cells and face life-threatening infections. A matched sibling donor transplant is the standard cure, but most babies do not have one. This trial tests a refined transplant using a parent or other partially m…
Matched conditions: SEVERE COMBINED IMMUNODEFICIENCY
Phase 1/2 • Sponsor: St. Jude Children's Research Hospital • Aim: Cure
Last updated Sep 18, 2026 00:00 UTC
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Milder stem cell transplant shows promise for kids with immune disorders
Disease control OngoingThis study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 part…
Matched conditions: SEVERE COMBINED IMMUNODEFICIENCY
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New stem cell approach could fix immune systems in kids
Disease control OngoingThis Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …
Matched conditions: SEVERE COMBINED IMMUNODEFICIENCY
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC