RETINAL DEGENERATION

This study tests whether metformin, a widely used diabetes medication, can safely slow the progression of vision loss in people with ABCA4 retinopathy (including Stargardt disease). Fifty-five participants aged 12 and older will take metformin daily for 24 months, with regular ey…

This study tests an experimental drug called VP-001 for people with a rare genetic eye disease that causes vision loss. The drug is injected into the eye and aims to slow or stop further damage. Researchers will check safety and measure any changes in eyesight over about two year…

This study looks at whether the drug ofatumumab can slow down thinning of the retina (the light-sensitive layer at the back of the eye) in people with relapsing-remitting multiple sclerosis (MS). Researchers will follow 75 adults with MS who are either starting or already taking …

This study follows 44 people with a rare genetic form of Usher syndrome caused by PCDH15 mutations. Over 48 months, researchers measure how their vision changes using eye exams and imaging. The goal is to identify the best ways to track disease progression, which will help design…

This study follows 68 people with ABCA4 gene mutations (linked to Stargardt disease and other retinal degenerations) for up to 10 years. Researchers collect blood and skin samples and perform detailed eye exams to track how the disease changes over time. No treatment is given; th…