REM SLEEP BEHAVIOR DISORDER (IRBD)

This study tests whether playing gentle sounds at night to enhance deep sleep can slow the progression of Parkinson's disease in 80 people with early-stage Parkinson's or a related sleep disorder (iRBD). Participants wear a headband and headphones for 18 months and undergo tests …

This study tests a 4-week online course that teaches people how to manage parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course provides education and self-management guidance. Researchers will measure if it reduces how often these events …

This study is following 650 people with either early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers are using brain scans, heart tests, and fluid samples to track how the disease changes over time. The goal is to better …

This study uses a new ultra-high-resolution PET scanner to see tiny brain structures in much more detail than before. Researchers will scan 300 healthy volunteers and people with Alzheimer's, Parkinson's, ALS, or psychotic disorders to find early signs of disease. The goal is to …

This study aims to understand how inflammation affects the brain in Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's and healthy volunteers, and use special brain scans to measure the response. Th…

This study looks at whether people with idiopathic REM sleep behavior disorder (iRBD) experience more pain than those with narcolepsy and RBD. iRBD is a strong early sign of Parkinson's disease, but pain in these patients has not been studied before. Researchers will compare pain…

This study looks at sleep problems in people with Parkinson's disease, those with a sleep disorder called REM sleep behavior disorder (iRBD), and healthy volunteers. Researchers will use overnight sleep tests to compare sleep quality among the three groups. The goal is to better …