Primary open-angle glaucoma

This trial tests a new gene-editing therapy called BD113vVLP for people with primary open-angle glaucoma caused by a specific genetic mutation (MYOC). The therapy is injected into the eye and aims to disable the faulty gene that leads to high eye pressure. The study will evaluate…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study tests whether taking nicotinamide and pyruvate supplements can help protect the eyes of people with open-angle glaucoma. About 250 adults aged 35 to 85 will take either the supplements or a placebo for 20 months, while continuing their standard glaucoma medications. Th…

This study tests a new device called the Helix Surgical System in people who have both primary open-angle glaucoma and cataracts. The device is used during cataract surgery to open up the eye's natural drainage channels, which may help lower eye pressure. The goal is to see if th…

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This study is testing a device called XEN63, a small implant placed in the eye to help drain fluid and lower pressure in people with glaucoma. Researchers will follow 96 patients for 24 months to see if the implant safely reduces eye pressure and the need for daily eye drops. The…

This early study tests a new drainage device for people with glaucoma, a condition where pressure builds up in the eye. The device is designed to self-adjust to help lower eye pressure. Ten participants will be followed to see if the device is safe and effective at reducing press…

This early study tests a new device called the GORE Glaucoma Drainage Implant in 30 adults with primary open-angle glaucoma that eye drops cannot control or who are at high risk of scarring from standard surgery. The goal is to see if the implant safely lowers eye pressure by at …

This study tests a new device called the VividWhite Glaucoma Implant, which is surgically placed in the eye to help lower pressure in people with glaucoma. Sixty-five participants will be followed for 12 months to see if the implant safely reduces eye pressure and lessens the nee…

This study tests smart soft contact lenses that measure eye pressure continuously for 24 hours in people with glaucoma and healthy adults. Researchers will check how accurate and comfortable the lenses are compared to standard eye pressure tests. The goal is to improve glaucoma c…

This study looks at whether a 12-week home exercise program (cycling and resistance training) can improve vision and quality of life in people with glaucoma. Researchers will measure changes in visual field sensitivity, eye blood flow, and oxygen use. The goal is to see if exerci…

This study looks at how vision loss from glaucoma affects the daily mobility of older adults. Researchers will give questionnaires to 88 people with glaucoma to measure how far they typically go from home and how they manage in dim light. The goal is to better understand the real…