PREMATURITY

This study tests whether giving preterm babies (born before 32 weeks) a drug called darbepoetin plus a slow-release intravenous iron can reduce the need for blood transfusions, keep iron levels healthy, and improve brain development. About 120 infants will be enrolled and compare…

This study looks at whether delivering medically tailored groceries to pregnant women on Medicaid can reduce food insecurity and improve pregnancy outcomes, like preventing preterm birth and low birthweight. About 360 pregnant women in Cuyahoga County, Ohio, will receive free gro…

This study tests whether adding azithromycin to the usual antibiotic (ampicillin) improves health outcomes for newborns when a woman's water breaks early (between 34 and 37 weeks of pregnancy). About 311 women will receive either ampicillin alone or ampicillin plus azithromycin w…

This study tests whether using a low or high flow rate on a non-invasive breathing machine changes carbon dioxide (CO2) levels in premature babies. About 45 preterm infants will each try both flow rates for a short time while their CO2 is monitored. The goal is to find the safest…

This study explores how a mother's stress may change the makeup of her breastmilk and how that affects feeding and brain development in preterm babies. Researchers will follow 120 preterm infants and their mothers from the NICU to 4 months corrected age. The goal is to better und…

This study explores whether playing music, with or without a parent's voice, can lower stress and improve brain development in very preterm infants (born 24-30 weeks). About 243 babies from two hospitals will be randomly assigned to music, music plus parent voice, or standard car…

This study looks at why some premature babies develop an eye problem called retinopathy of prematurity (ROP). Researchers think that fatty acids from the mother may play a role. They will measure fatty acid receptors in the placenta and compare them between mothers of premature a…

This study looks at whether giving very premature babies (born 27-31 weeks) a higher or lower amount of human milk helps them grow better and have healthier guts. About 486 babies will be randomly assigned to one of two milk volumes. The goal is to find the best feeding plan for …