PREGNANCY, HIGH-RISK

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants wil…

This study tests whether using a continuous glucose monitor (CGM) instead of standard fingerstick checks helps pregnant women with type 2 diabetes have healthier babies. About 180 women will be randomly assigned to use a CGM or continue usual care. The main goal is to see if CGM …

This study compares two treatments for gestational diabetes—metformin pills versus insulin shots—in 1,572 pregnant women across 20 U.S. sites. The goal is to see if metformin works as well as insulin to prevent serious problems for the baby and mother, and to track the health of …

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether taking the blood thinner Lovenox three times a day works better than the standard twice-a-day schedule for pregnant women at high risk of blood clots. Pregnancy increases clot risk fivefold, and many women on the standard schedule don't get enough protect…

This study aims to see if screening for gestational diabetes earlier in pregnancy (first trimester) is feasible and acceptable for high-risk women. About 80 pregnant women at high risk for gestational diabetes will be invited to participate. The goal is to catch the condition soo…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests whether offering a diabetes test right after delivery (instead of waiting 4-12 weeks) helps more women get screened. It also surveys women with a history of gestational diabetes to understand what helps or hinders heart health counseling and lifestyle changes. Ab…

This study is following over 267,000 pregnant women in low- and middle-income countries to understand what factors lead to serious problems like stillbirth, maternal death, and preterm birth. Researchers will collect health data from before 20 weeks of pregnancy through the first…