POSTOPERATIVE DELIRIUM (POD)

This study tests whether a step-by-step plan to manage body temperature during a long surgery can lower the chance of postoperative delirium (sudden confusion). The surgery is for a rare abdominal tumor called pseudomyxoma peritonei and involves heated chemotherapy. The trial wil…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can prevent postoperative delirium—sudden confusion—in older adults after urological surgery. About 220 people aged 60 and older will receive TMS during surgery. Res…

This study tests whether a nasal spray called dexmedetomidine, taken at night, can help older adults (ages 65-90) sleep and reduce the risk of delirium after major abdominal surgery. 400 participants will be randomly assigned to receive either the drug or a placebo. The goal is t…

This study tests whether a dexmedetomidine nasal spray can lower the chance of postoperative delirium (sudden confusion) in elderly patients after lung surgery. About 264 people aged 65 and older will be randomly assigned to receive either the spray or a placebo. Researchers will…

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults before, during, and after heart surgery. The goal is to find which biological and clinical markers best predict early complications like delirium, kidney injury, and bleeding. Researche…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …