PERITONEAL CARCINOMATOSIS

This study is for people with stomach cancer that has spread to the lining of the abdomen. It compares standard chemotherapy given through a vein to the same treatment plus an extra chemotherapy drug (paclitaxel) delivered directly into the belly through a small port. The goal is…

This study tests if giving chemotherapy as a mist directly into the belly (PIPAC) along with standard IV chemo can help women with advanced ovarian cancer. The goal is to see if it makes surgery more successful and improves survival. About 160 women aged 18-75 with stage IIIB-III…

This early-phase trial is testing a procedure called PIPAC, which turns liquid chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. It is for people with ovarian, uterine, appendix, colorectal, or stomach cancer that has spread to the li…

This early-phase trial tests a new treatment for people with a type of stomach cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goals are to chec…

This study tests a new treatment called Radspherin® for people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has spread in the abdomen. Participants receive a single injection of radioactive beads into the belly during surgery, alongside standard chemot…

This study is for women with advanced ovarian, fallopian tube, or peritoneal cancer whose tumors did not shrink enough with standard chemotherapy. Researchers are testing a new method called PIPAC, which delivers chemotherapy as a spray directly into the abdomen, alongside standa…

This study compares two methods of delivering chemotherapy directly into the abdomen for people with cancer that has spread there (peritoneal carcinomatosis). One method uses heated chemotherapy during surgery (HIPEC), the other uses a pressurized spray during a minimally invasiv…

This study tests a modified, shorter chemotherapy schedule given directly into the abdomen after surgery for cancers that have spread to the lining of the belly. The goal is to see if this two-day treatment is easier to complete than the standard five-day version. About 25 adults…

This study looks at two methods of giving heated chemotherapy directly into the abdomen during surgery for advanced gastrointestinal cancers that have spread to the lining of the belly. About 100 people will be randomly assigned to receive either a standard flat dose or a dose ba…

This study tests a simple breathing technique called cardiac coherence to help reduce anxiety in people awaiting surgery for peritoneal cancer. About 60 participants will practice guided breathing sessions daily before their operation. The goal is to see if this easy, drug-free m…

This study looks at whether a special set of care steps called an Enhanced Recovery After Surgery (ERAS) protocol can help people recover faster after surgery for peritoneal carcinomatosis (cancer that has spread in the abdomen). About 300 people will take part across 20 hospital…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can help surgeons see cancerous lesions during surgery for gastrointestinal cancer that has spread to the lining of the abdomen. Ten adults with this condition will receive the dye before surgery, a…

This study is for adults with cancers that have spread to the lining of the abdomen. Doctors will remove most tumors during surgery, then give heated chemotherapy directly into the abdomen. They will also test the same chemo on tumor samples in the lab to see if lab results match…

This study looks at how certain substances in the blood (nucleosomes and CTCF) change after surgery to remove colorectal cancer that has spread to the abdomen. The goal is to find a better way to tell if any cancer cells remain after the operation. About 58 adults having surgery …

This study looks at whether giving heated chemotherapy directly into the abdomen during keyhole surgery can increase a protein called PD-L1 in stomach cancer that has spread to the lining of the belly. PD-L1 helps doctors decide if immunotherapy might work. The trial involves 21 …