PEDIATRIC ALL

This study tests a new treatment for children and young adults (up to age 21) with a type of leukemia (CD19-positive) that has returned or not responded to standard therapy. The treatment uses specially engineered immune cells from a family donor to attack the cancer. The main go…

This study looks at whether Omegaven, a special IV fat source, is safe for children under 18 who have liver problems caused by long-term IV feeding. About 40 kids will be monitored for signs of essential fatty acid deficiency, like dry skin or poor growth, over at least 8 weeks. …

This study tests whether a home-based exercise bike linked to a video game (MedBIKE) can help 10 children, aged 10-18, who have had a heart transplant improve their fitness. The program lasts 12 weeks and uses short, intense bursts of exercise. The main goal is to see if the prog…

This study looks at whether a special brain wave (EEG) score can predict if a child will need more sedation for a successful brain MRI. About 50 children under 5 (or older children at risk of movement) will receive a standard dose of sedation, and their EEG score will be checked.…

This study aims to create a simple, accurate tool using sensors and machine learning to detect motor delays in babies as young as 1 month old. Researchers will observe 1,700 infants, including those with brain injuries and healthy controls, to see if the technology can predict fu…

This study looks at whether a computer tool called pediatric eCART can help doctors quickly identify hospitalized children at high risk for serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, involving up …

This study tests if a home-based video game exercise bike can improve fitness in 44 teens (ages 10-18) with repaired congenital heart disease. Participants use the MedBIKE for high-intensity interval training, guided remotely by a coach. The goal is to see if this fun, telemedici…

This study looks at whether giving sugammadex, a drug that reverses muscle relaxants, can reduce the chance of children waking up confused and agitated after strabismus (eye muscle) surgery. About 76 children aged 4 to 7 will take part. The goal is to see if sugammadex works bett…

This study tests which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most. Participants will attend weekly…

This study gathers movement data from 40 healthy children and teens aged 3 to 25. Using cameras and force plates, researchers measure how they move during activities. The goal is to create a baseline of normal movement, which can later help doctors better understand and treat kid…

This study is for children aged 10-18 with certain heart conditions or who have had a heart transplant. Researchers will use special MRI scans taken during exercise to see how the heart and skeletal muscles work together. The goal is to learn more about what affects fitness in th…

This study looks back at medical records and brain MRI scans from up to 2000 children (healthy and with developmental delays) to create computer models that link brain images with genetic information. The goal is to better understand and predict developmental disorders, but no ne…

This study looks at how children under 21 with a type of leukemia (ALL) process medicines they already take as part of their standard care. Researchers will measure drug levels in the blood to better understand dosing. About 200 children will join, and no extra drugs or treatment…

This study follows 40 people who received Miltenyi CAR T cell therapy at least one year ago. Researchers will track side effects, blood cell counts, growth, and overall health over time. The goal is to understand the long-term safety of these treatments.

This study follows 4,000 children who already have or will receive orthopedic implants (like rods, screws, or plates) for bone fractures, deformities, or hip problems. Researchers will monitor how well the implants work, how long they last, and any side effects over time. The goa…

This study looks at whether pulse oximeters—the clip-on devices that measure oxygen levels—are equally accurate for children of all skin colors. Researchers will compare readings from the device with a precise blood test in 650 children undergoing heart catheterization. The goal …