Patent foramen ovale
Clinical trials for Patent foramen ovale explained in plain language.
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New heart device aims to prevent strokes in patients with a hole in the heart
Disease control OngoingThis study tests a new device called the Occlutech Flex II PFO Occluder, which is used to close a small hole in the heart (PFO) that can cause strokes. The trial involves 450 people who have had a stroke with no clear cause and a PFO. Researchers want to see if the new device wor…
Matched conditions: PATENT FORAMEN OVALE
Sponsor: Occlutech International AB • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Heart device aims to cut stroke risk in PFO patients
Disease control OngoingThis study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…
Matched conditions: PATENT FORAMEN OVALE
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Can a common heart drug stop rhythm problems after a Stroke-Related heart repair?
Prevention OngoingResearchers test whether flecainide, an antiarrhythmic drug, can prevent atrial arrhythmias in adults who have a patent foramen ovale (PFO) closed after a cryptogenic stroke. Participants receive flecainide or standard care for 3 to 6 months. An insertable cardiac monitor records…
Matched conditions: PATENT FORAMEN OVALE
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
Knowledge-focused OngoingResearchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…
Matched conditions: PATENT FORAMEN OVALE
Sponsor: Luciano A. Sposato • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC