Overactive bladder (OAB)

This trial compares two non-invasive treatments for overactive bladder (OAB): transcutaneous peroneal electrical neuromodulation, which uses surface electrodes to stimulate a nerve in the leg, and pelvic floor exercises, a standard behavioral therapy. Adults with idiopathic OAB w…

This phase 3 trial is testing a wearable device that stimulates a nerve in the calf to see if it can reduce the sudden, urgent need to urinate that defines overactive bladder. About 290 adults with overactive bladder symptoms will be randomly assigned to use the device daily or t…

This study compares two common medications for overactive bladder (OAB): solifenacin, which blocks nerve signals in the bladder, and mirabegron, which helps the bladder muscle relax. Researchers want to see if a person's 'anticholinergic burden'—the combined effect of other medic…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This study tests whether applying mild electrical pulses (TENS) to the shins can reduce pain and anxiety in people receiving Botox injections into the bladder for overactive bladder. Participants are randomly assigned to receive either active TENS or a sham device during the inje…

This study will test whether a wearable device that stimulates a nerve in the leg can help women with overactive bladder and frequent nighttime urination. Participants will either use the device plus behavioral therapy or behavioral therapy alone. The goal is to see if the device…

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study tests a new treatment called TRG-200 KIT for people with overactive bladder (OAB) who haven't found relief from standard therapies. The treatment is given once a month through a catheter into the bladder and slowly releases medication to reduce urgent bathroom trips an…

This study tests if a gentle heat treatment (45-50°C) delivered through the vagina can calm overactive bladder symptoms. The heat targets nerve endings in the bladder muscle to reduce urgency and leakage. About 48 adults with moderate to severe symptoms will receive this office-b…

This study looks at whether transcutaneous electrical nerve stimulation (TENS), a treatment for overactive bladder, also affects the autonomic nervous system—the part of the body that controls heart rate and stress responses. Researchers will measure heart rate variability in adu…

This study looks at whether simple blood tests can predict how well women with overactive bladder respond to the drug mirabegron. Researchers will measure inflammation markers in the blood before treatment and see if they relate to symptom improvement after three months. The goal…

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…