Osteoarthritis (OA)

This trial compares two common surgeries for end-stage ankle arthritis: ankle fusion (arthrodesis) and ankle replacement (arthroplasty). It aims to see which procedure better improves daily function, reduces pain, and enhances quality of life. Adults with ankle arthritis who are …

This phase 2 trial tested an experimental drug called LRX712, given as injections into the knee, to see if it can help regrow cartilage in people with mild to moderate knee osteoarthritis. 45 participants received either the drug or a placebo over 8 weeks. The main goal was to me…

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain an…

Researchers are testing whether combining extracorporeal shockwave therapy with injections of hyaluronic acid or platelet-rich plasma eases pain and improves knee function better than shockwave therapy alone in people with moderate to severe knee osteoarthritis. The trial enrolls…

This study uses ultrasound to measure the thickness of ankle cartilage in people with spinal cord injuries and compares it to healthy individuals. The goal is to see if cartilage damage starts early, which could help prevent osteoarthritis. Researchers will also assess participan…