OSTEO ARTHRITIS KNEE

This study compares two types of knee replacement surgery for people with severe knee arthritis: a total knee replacement done by hand and a partial knee replacement done with a robot. The goal is to see which approach gives better knee function and is more cost-effective. About …

This study checks if a surgical robot called ROSA Knee can help surgeons make last-minute changes to a knee replacement plan based on how the patient's soft tissues look during the operation. About 80 adults with knee arthritis will take part and be followed for two years. The go…

This study tests whether adding metformin, a diabetes drug, to standard care can reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 30 to 60 with moderate knee arthritis will take metformin or a placebo alongside their usual treatments. The …

This study tests a new treatment called OA-SYS for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and well-tolerated. Researchers will also check if it reduces pain and the need for pain relievers. About 400 adults aged 35 to 75 with kne…

This study tests whether combining two types of injections—platelet-rich plasma (PRP) and hyaluronic acid—works better than either alone for knee osteoarthritis. About 288 adults aged 40-75 with knee pain will receive one of three treatments and be monitored for changes in pain, …

This study tests different types and doses of vitamin K in people aged 60 and older with knee osteoarthritis. The goal is to see if vitamin K can improve markers related to joint health. Participants will take vitamin K pills and have blood tests over the study period.

This study compares two ways to manage pain after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which method helps people walk farther and recover faster without increasing fall risk. About 220 …

This study tests whether using a whole-body vibration machine at home for 12 weeks can reduce knee pain and inflammation in people with osteoarthritis. Researchers will measure pain sensitivity, blood vessel function, and inflammation levels in 30 adults aged 40-75. The goal is t…

This study tests whether adding a therapy that involves breathing air with low and then high oxygen levels (intermittent hypoxia-hyperoxia) to standard physical therapy can better reduce pain and improve daily function in people with knee osteoarthritis. The trial will include 60…

This study is testing a device called the MISHA Knee System to see if it safely reduces pain and improves knee function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from other treatments will receive the implant and be follo…

This study looks at whether adding a fall prevention program to regular physical therapy can reduce falls and improve balance in older women who have had a total knee replacement. About 90 participants will be followed for 24 weeks. The goal is to help seniors recover more safely…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and arthritis will receive one of the two injections and be followed for up to a year. The goal is to see if the hydrogel provid…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …