OPIOID DEPENDENCE

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study tests a community program called Young HEROES that helps young people with opioid use disorder. The program combines medication, counseling, and peer support to keep them in treatment and reduce opioid use. Researchers will track how many youth stay in treatment and st…

This early-stage study tests two new long-acting injections, IVL3004 and IVL4002, in 40 healthy men aged 18-55. The goal is to see how the body processes these drugs compared to the approved medication Vivitrol, and to check for safety. If successful, these injections could offer…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. About 24 adults who have been on opioids for at least 4 weeks will take lacosamide for 7…

This study looks at four different programs to help cancer survivors who have been on strong painkillers (opioids) for a long time reduce or stop using them. The goal is to find safe alternatives that control pain without the risk of addiction or overdose. About 294 veterans who …

This study explores whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two guided therapy sessions over 8 weeks, wit…

This study tests a program for adults who take opioids for chronic pain before surgery. The program includes pain education, therapy, and a mobile app to help patients reduce opioid use and manage pain better after surgery. Researchers will compare how many patients successfully …

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the patch or a placebo, along with standard pain care…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…