OPIOID DEPENDENCE

This study is testing whether adding counseling and community peer support to standard buprenorphine treatment helps people with opioid addiction stay in treatment and engaged with their healthcare team. Researchers will compare the enhanced program against usual care for 70 part…

This small pilot study is testing whether therapy sessions using the psychedelic compound psilocybin can help people with chronic pain safely reduce or stop their opioid pain medications. The study will involve 10 adults who have previously struggled to taper off opioids. Partici…

This study tests a community program to help young people with opioid addiction. It combines outreach workers, medication treatment, counseling, and peer support to help participants stay in treatment longer. The goal is to reduce overdoses and help youth maintain recovery from o…

This early study is testing two new long-acting injection versions of a medication called naltrexone, which is used to help manage opioid and alcohol dependence. The study will involve 40 healthy male volunteers to see how the body processes these new injections compared to the e…

This study aims to help cancer survivors who have chronic pain reduce their long-term opioid use safely. It will test four different treatment approaches, including specialized pain care and medication changes, to see which works best. The goal is to lower opioid doses by at leas…

This early-stage study is testing whether adding an existing epilepsy drug, lacosamide, to standard opioid painkillers is safe and tolerable for adults with chronic pancreatitis. The main goal is to see if the combination helps reduce severe abdominal pain and might allow patient…

This study aims to understand why some people relapse after starting medication treatment for opioid addiction. Researchers will use brain scans on 240 people recently starting treatment to look for patterns linked to staying drug-free. The goal is to learn how the brain changes …