Open tibia fracture
Clinical trials for Open tibia fracture explained in plain language.
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Can operating within 72 hours save limbs after severe leg trauma?
Disease control Not yet recruitingResearchers are comparing two timings for flap surgery in adults with severe open fractures or dislocations below the knee. One group receives a flap within 72 hours of injury, while the other follows the standard timing used at each hospital. The trial measures death, amputation…
Matched conditions: OPEN TIBIA FRACTURE
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Can a low-cost wound vacuum prevent infections after severe leg fractures?
Disease control Not yet recruitingThis pilot trial tests whether a low-cost negative pressure wound therapy (NPWT) system is a practical alternative to standard dressings for severe open tibia fractures in a low-resource setting. Researchers will randomly assign 66 adults with Gustilo-Anderson type IIIb open tibi…
Matched conditions: OPEN TIBIA FRACTURE
Sponsor: Université Catholique de Bukavu • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Ethiopian surgery infection study aims to save lives and limbs
Prevention Not yet recruitingThis study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…
Matched conditions: OPEN TIBIA FRACTURE
Sponsor: Karolinska Institutet • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC