Obstructive hypertrophic cardiomyopathy (OHCM)
Clinical trials for Obstructive hypertrophic cardiomyopathy (OHCM) explained in plain language.
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Testing whether beta-blockers can be dropped once mavacamten steadies a thickened heart
Disease control Not yet recruitingResearchers are testing whether adults with obstructive hypertrophic cardiomyopathy can safely taper off beta-blockers after their heart condition has stabilized on mavacamten. The trial enrolls 286 people aged 18 to 75 who have been on a stable dose of mavacamten and one beta-bl…
Matched conditions: OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (OHCM)
Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can smarter dosing of mavacamten unblock the heart more effectively?
Disease control Not yet recruitingThis study tests whether adjusting the dose of mavacamten based on heart pumping strength can further reduce the blockage of blood flow in people with obstructive hypertrophic cardiomyopathy. Participants are adults who have been on a stable mavacamten dose for at least 12 weeks …
Matched conditions: OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (OHCM)
Phase 4 • Sponsor: Second Affiliated Hospital of Nanchang University • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Gene test may personalize heart drug dosing
Knowledge-focused Not yet recruitingThis study looks at how a person's genes affect their response to the heart drug mavacamten for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see which genetic types respond best. The goal is to improve dosing safety and effect…
Matched conditions: OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (OHCM)
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC