NEOPLASM METASTASIS

This early-stage study is testing the safety and initial effectiveness of a new drug called MK-6837, given alone and in combination with an existing immunotherapy (pembrolizumab). It involves 168 adults with advanced or metastatic solid tumors that have not responded to standard …

This early-stage trial is testing a new oral drug called zongertinib for people with advanced solid tumors that have specific changes in the HER2 gene. The first part aims to find the highest safe dose. The second part will test if that dose can shrink tumors, especially in peopl…

This study allows people with metastatic breast cancer who were benefiting from a targeted drug called trastuzumab emtansine in a previous trial to continue receiving it. The main goal is to monitor the long-term safety of the treatment in about 720 participants. It is not testin…

This study is testing whether adding a drug called abemaciclib to standard chemotherapy (irinotecan and temozolomide) works better for controlling Ewing's sarcoma that has come back or stopped responding to treatment. It involves about 46 children and young adults. The main goal …

This study is for people with a specific type of advanced breast cancer that has continued to grow despite previous hormone therapy and a targeted drug. It tests whether adding a medication called abemaciclib to standard fulvestrant therapy is better at controlling the cancer tha…

This study is testing whether a non-surgical treatment using focused sound waves (MR-HIFU), either alone or combined with standard radiation therapy, can relieve pain from cancer that has spread to the bones faster and better than radiation alone. It involves about 216 adult pati…