NASH - NONALCOHOLIC STEATOHEPATITIS

This study tests whether atorvastatin (Lipitor), a widely used cholesterol medication, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo. The goal is…

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have received a liver transplant and have poorly controlled diabetes. The goal is to see which drug better improves blood sugar control and reduces body weight. Participants will take one …

This study looks at whether a supervised ketogenic diet is safe and effective for weight loss in 40 obese adults with NASH cirrhosis. Participants are randomly assigned to either the ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liver com…

This study tests a drug called lanifibranor in 1,000 adults with non-alcoholic fatty liver disease (NASH) and moderate liver scarring (stages F2 or F3). The goal is to see if the drug can reduce liver inflammation and scarring over 72 weeks. Participants are randomly assigned to …

This study tests a drug called resmetirom in about 1,759 adults with NASH, a fatty liver disease that can lead to scarring and liver failure. The goal is to see if the drug can reverse the liver damage or stop it from getting worse over 54 months. Participants take either 80 mg, …

This study tests a new drug, HM15211, for people with NASH, a serious fatty liver disease that can lead to scarring. About 215 adults with confirmed NASH and liver scarring will receive the drug or a placebo for 12 months. The main goal is to see if the drug can reduce liver infl…

This study tests whether a natural compound called tocotrienol (a form of vitamin E) can slow the worsening of end-stage liver disease in 70 adults with cirrhosis. Participants take either tocotrienol capsules or a placebo twice daily for 3 years. The goal is to see if the treatm…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) before and after a type of weight-loss surgery called sleeve gastrectomy. About 30 adults who are overweight and have NASH or prediabetes will take part. Th…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses over time. Researchers use non-invasive scans to measure liver fat and stiffness at the start and after one year. The goal is to fill major knowledge gaps, since people with HI…

This study tests a new MRI technique that measures liver stiffness and viscosity to identify NASH patients at higher risk for liver cancer. About 35 adults with NASH and early-stage liver scarring will undergo a longer MRI scan. The goal is to see if this imaging method can predi…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …