NASH - nonalcoholic steatohepatitis

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples bef…

This trial tests whether an estradiol patch can reduce liver fat and scarring in postmenopausal women with NASH, a progressive form of fatty liver disease. The study enrolls women aged 45-70 with NASH or fatty liver, giving them either a daily estradiol patch or a placebo for a p…

This study tests a drug called lanifibranor in 1000 adults with NASH (a fatty liver disease) and moderate liver scarring (stages F2 or F3). The goal is to see if the drug can reverse the scarring and reduce liver inflammation over 72 weeks. Participants are randomly assigned to r…

This Phase 3 trial tests whether the drug resmetirom (MGL-3196) can reverse liver scarring (fibrosis) and stop NASH from progressing to cirrhosis or liver failure. About 1,759 adults with NASH and liver fibrosis will receive either resmetirom or a placebo daily for up to 54 month…

This study tests whether a monitored ketogenic diet is safe and effective for weight loss in 40 obese adults with compensated NASH cirrhosis. Participants are randomly assigned to either a ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liv…

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have had a liver transplant and have poorly controlled diabetes. The goal is to see which drug better lowers blood sugar and body weight. Participants will take the study drug daily for th…

This study tests whether atorvastatin (Lipitor), a widely used cholesterol medication, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo. The goal is…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study tests a new, longer MRI scan that measures liver stiffness and viscosity to see if it can identify NASH patients at higher risk for liver cancer. About 35 adults with NASH and early-stage liver scarring will participate. The goal is to improve early detection, not to t…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers will use a non-invasive scan to measure liver stiffness and fat content over one year. The goal is to fill major knowledge gaps, since p…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…