MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Clinical trials for MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE explained in plain language.
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Pill vs. IV: Head-to-Head race to slow debilitating MS
Disease control OngoingThis large, late-stage study is testing whether a new daily oral medication, fenebrutinib, can slow the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). It directly compares fenebrutinib against an existing intravenous (IV) treatment, ocrelizu…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Major trial tests drug to halt worsening disability in progressive MS
Disease control OngoingThis large, late-stage study is testing whether the drug ocrelizumab (Ocrevus®) can slow down the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). Over 1,000 participants were randomly assigned to receive either the drug or a placebo (inactive…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Common supplement tested to protect brains in progressive MS
Disease control OngoingThis study is testing whether N-acetyl cysteine (NAC), an over-the-counter antioxidant supplement, can slow brain shrinkage in people with progressive multiple sclerosis. 98 participants aged 40-70 with progressive MS will receive either NAC or a placebo for 15 months. Researcher…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE2 • Sponsor: Emmanuelle Waubant, MD PhD • Aim: Disease control
Last updated Mar 17, 2026 12:55 UTC
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Brain scans unlock mystery of MS memory loss
Knowledge-focused OngoingThis study aims to understand how thinking and memory problems develop over time in people with primary progressive multiple sclerosis (PPMS). Researchers will follow 66 participants for 2 years, using brain scans and detailed thinking tests to see how brain changes relate to cog…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:41 UTC