MOTOR NEURON DISEASE

This early study tests a device implanted in a blood vessel in the brain that lets people with ALS control computers or devices just by thinking. The goal is to help with daily tasks and improve quality of life. Ten adults with ALS who have weakness in both arms will be enrolled …

This study tests a brain-computer interface (BCI) implant for people with ALS or motor neuron disease who have weakness in both arms. The device aims to let them control computers or other devices just by thinking. The main goal is to check safety, such as serious side effects, o…

This study is testing whether a smartphone app can help diagnose and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by recording and analyzing speech. Researchers will compare speech patterns from 150 people with these conditions t…

This study is testing a new, painless technique called electrical impedance myography (EIM) to see how well it measures muscle health in people with and without neuromuscular diseases. Researchers will compare EIM results with standard tests like ultrasound and nerve studies. The…

This study aims to learn more about rare inherited neurological disorders by observing up to 3,500 people with these conditions and their relatives. Researchers will collect medical history, perform exams, and take blood or skin samples to study genetics and disease progression. …

This study is creating a large collection of blood, spinal fluid, and urine samples from 800 people with ALS and 200 healthy volunteers. Researchers will also track symptoms and physical function over time. The goal is to provide this data to scientists worldwide to help them bet…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study looks at men with spinal and bulbar muscular atrophy (SBMA), also called Kennedy's disease, to find ways to measure how the disease progresses over time. Researchers will use muscle tests, imaging scans, and lab tests to track changes. The goal is to identify reliable …

This study looks at how physical abilities affect the quality of life in people with ALS, a disease that weakens muscles over time. Researchers will ask 30 participants to fill out questionnaires about their daily life and physical function during regular clinic visits for two ye…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…