MLH1 GENE MUTATION

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, precancerous polyps, and Lynch syndrome-related cancers early. Researchers will collect blood from 1,200 people who have already had a colonoscopy and see how accurate the test is…

This study looks at two new approaches to cancer genetic counseling. The first part (EfFORT) tests whether having healthcare providers directly contact family members of people with harmful gene changes leads to more genetic testing, compared to the usual method of patients telli…

This study looks at a specific gene change (called hMLH1 hypermethylation) in stomach cancer to understand why it happens and how it affects treatment. Researchers will study 245 patients who had stomach cancer surgery to find links between lifestyle, diet, and this gene change. …

This study looks at how the immune system's surveillance affects the development of colorectal cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will follow 300 participants with Lynch syndrome who are already undergoing regular cancer…

This study looks at how well a tiny camera you swallow (videocapsule endoscopy) can find early signs of small bowel cancer in people with Lynch syndrome. About 100 adults with Lynch syndrome will swallow the camera pill as part of their regular care. Researchers will track how ma…