MELANOMA (SKIN CANCER)

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can improve outcomes for people with a rare type of skin cancer called acral melanoma. About 30 adults with stage IIB or III melanoma that can be removed will receive the drugs…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests a special PET scan that uses a radioactive probe to detect PD-L1, a protein on tumor cells, in people with lung cancer, melanoma, or other solid tumors. The goal is to see if this scan can predict who will benefit from immunotherapy. About 40 adults aged 18-75 wh…

This study tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults will get both tracers before surgery, and doctors will compare how often each method finds …

This study looks at whether smartphone apps can help people who have had melanoma avoid too much sun. About 150 participants will wear a UV sensor and activity tracker, answer daily surveys, and try up to five different app-based sun protection programs. The goal is to see which …

This study tests a new rehabilitation program for people with melanoma, a serious skin cancer. The program includes exercises and support before and after surgery to help patients regain strength and confidence. The study will include 30 adults who are scheduled for surgery after…

This study looks at whether tiny particles in the blood, called extracellular vesicles, can help doctors predict if immunotherapy will work for people with advanced lung cancer or melanoma. Researchers will collect blood samples from 378 patients before and during standard treatm…

This study looks at whether the way fat cells and immune cells interact in melanoma skin cancer can help predict if the cancer will spread. Researchers will examine tissue samples from 20 patients to see if certain patterns are linked to more aggressive disease. The goal is to be…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study tests whether using a Fitbit and weekly symptom surveys can help doctors remotely monitor people with advanced melanoma who are starting immunotherapy. About 40 participants will be randomly assigned to use the digital monitoring tool or standard care. The goal is to s…

This study aims to develop a blood test that can predict whether a patient with certain cancers (like lung, skin, or breast cancer) will benefit from immunotherapy. Researchers will analyze a specific type of white blood cell (neutrophils) from blood samples taken before treatmen…