Major depression disorder
Clinical trials for Major depression disorder explained in plain language.
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Psychedelic DMT studied for depression relief in early human trial
Symptom relief Recruiting nowThis Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is t…
Matched conditions: MAJOR DEPRESSION DISORDER
Phase 1 • Sponsor: Deepak C. D'Souza • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Could a headset at home lift depression? new trial investigates
Symptom relief Recruiting nowThis study compares the safety and effectiveness of using a mild electrical brain stimulation device (tDCS) at home versus at a clinic for treating major depression. About 198 adults with moderate to severe depression will use the device daily for a few weeks. Researchers will me…
Matched conditions: MAJOR DEPRESSION DISORDER
Sponsor: Ionclinics & Deionic SL • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Could a light beam lift depression when drugs fail?
Symptom relief Recruiting nowThis study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) on the forehead to help people with treatment-resistant depression. About 40 adults who still have moderate-to-severe depression despite taking antidepressants will receive tPBM at differe…
Matched conditions: MAJOR DEPRESSION DISORDER
Sponsor: Taipei Veterans General Hospital, Taiwan • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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Can a blood test predict who benefits from magnetic brain stimulation?
Knowledge-focused Recruiting nowResearchers are studying whether blood proteins and metabolites can predict who responds to transcranial magnetic stimulation (TMS) for treatment-resistant depression. About 55 adults whose depression has not improved with at least two antidepressants receive 20 sessions of inter…
Matched conditions: MAJOR DEPRESSION DISORDER
Sponsor: Gulhane Training and Research Hospital • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
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Which ketamine works better for severe depression? a 5-Year study aims to find out
Knowledge-focused Recruiting nowThis study follows 450 people with treatment-resistant depression who are starting or continuing treatment with either IV ketamine or Spravato (esketamine) nasal spray. Over five years, researchers will track how satisfied patients are with their treatment, how well it works, and…
Matched conditions: MAJOR DEPRESSION DISORDER
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC