LYMPHOBLASTIC LYMPHOMA

This study tests whether removing a specific type of immune cell (naive T cells) from donated stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body, causing long-term…

This study tests a new way to prepare donor stem cells for transplant in people with blood cancers like leukemia. By removing certain immune cells from the donated cells, researchers hope to lower the risk of graft-versus-host disease, a serious side effect. The study involves 70…

This study tests a combination of chemotherapy drugs (DA-EPOCH) plus a targeted pill (ponatinib) in adults newly diagnosed with a fast-growing blood cancer called Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this approach is safe …

This study tests a stem cell transplant method for people under 25 with certain blood cancers. The approach filters out specific immune cells from donated stem cells to lower the risk of graft-versus-host disease (a serious complication) while helping the new cells grow. Up to 40…

This study is for children under 25 who have had a stem cell transplant for blood cancers like leukemia. After transplant, their immune system is weak, putting them at high risk for dangerous infections. Researchers are adding back a specific type of donor cell (CD45RA-depleted) …

This study tests a new experimental drug, LP-118, combined with three other medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The goal is to find a safe dose and s…

This study looks at whether a drug called dexrazoxane can help prevent heart problems in children and teens who have been treated for certain cancers like leukemia or lymphoma. Researchers will check blood samples and heart scans from about 420 survivors to see how well the drug …

This study tests a new form of the drug asparaginase (made from a different bacterium) combined with standard chemotherapy in 53 high-risk adults aged 18–54 with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if the combination is safe …

This study tests a treatment called CAR T-cell therapy for people with advanced B-cell leukemias or lymphomas that haven't responded to standard drugs. Participants' own immune cells are collected, modified in a lab to recognize and attack cancer cells, and then returned to the b…

This study tests a stem cell transplant from a half-matched donor for people with blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare the body. The goal is to see if this approach helps the new stem cells grow and fight cancer wit…

This study tests a treatment called WU-CART-007 for people with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma that has come back or not responded to other treatments. The therapy uses donor immune cells that are modified to find and attack cancer cells. The main g…

This study is for children and young adults (ages 1-18) with newly diagnosed B-cell acute lymphoblastic leukemia or lymphoma. It tests a combination of two targeted immunotherapy drugs, inotuzumab and blinatumomab, given early in treatment. The goal is to see if this approach can…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after transplant. About 46 people with various blood cancers or disorders will take part. The goal i…

This study enrolls children aged 1 to 18 with newly diagnosed acute lymphoblastic leukemia, lymphoblastic lymphoma, or mixed phenotype acute leukemia. The main goal is to give enough initial treatment while doctors gather genetic and lab information to decide the best risk-based …

This study will look at the medical records of 18,000 children, adolescents, and young adults with cancer in low- and middle-income countries. The goal is to understand how often treatment fails or causes harmful side effects, especially for leukemia and lymphoma. The findings wi…

This study is testing a new mobile app that sends timely reminders and support to help teens and young adults (ages 14-29) with acute lymphoblastic leukemia or lymphoma take their oral chemotherapy pills as prescribed. The study enrolls 60 participants who are in the maintenance …