LOCALIZED PROSTATE CARCINOMA

This study compares two radiation therapy schedules for men with localized prostate cancer. One uses fewer, stronger doses (ultra-hypofractionated) and the other uses slightly more, moderate doses. Both are combined with a brachytherapy boost. The goal is to see which approach ca…

This study is testing a new type of radiation therapy that adapts to the patient's anatomy in real time. It is for men with localized prostate cancer who also have an enlarged prostate or urinary symptoms. The goal is to see if this approach can reduce side effects while still ef…

This study tests how well a short course of hormone therapy (ADT) shrinks high-risk prostate cancer before surgery. About 50 men will get ADT, then have PSMA PET scans to see if the cancer shrinks. The goal is to see if this approach can improve outcomes after prostate removal.

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This early-stage study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affec…

This study is testing a special MRI technique that uses a substance called hyperpolarized pyruvate to see if it can better find high-grade prostate cancer (the more aggressive type). About 80 men scheduled for prostate removal surgery will get this scan. The goal is to see if thi…

This study tests whether a special PET/MRI scan can accurately predict if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer will get the scan before surgery to remove the prostate. The goal is to see if the scan can identify who truly n…

This study tests a special tissue wrap placed on nerve bundles during prostate removal surgery. The goal is to see if it helps men recover erectile function and bladder control faster. About 25 men with localized prostate cancer will take part. The wrap is meant to protect nerves…

This study tests whether a supervised golf exercise program can help prostate cancer survivors who are on hormone therapy improve their physical function, mental health, and quality of life. Twenty men aged 55-85 with little or no golf experience will take part. The program inclu…

This study compares a standard survivorship care plan to one that is simplified for people with lower health literacy. Researchers want to see if the tailored plan helps African American prostate cancer patients better understand their treatment side effects and follow-up needs. …

This study is for 100 men with low-risk or early intermediate-risk prostate cancer who will receive a type of radiation called HDR brachytherapy. Researchers will use advanced lab tests to see how the radiation changes the cancer's chemistry and the body's immune response. The go…

This study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…