KETAMINE

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests whether breathing in a mist of ketamine can quickly reduce symptoms of moderate to severe depression in hospitalized adults. About 40 participants will receive either ketamine or an active placebo (midazolam) to see if the ketamine mist works better. The goal is …

This study looks at 40 people with heart disease and weak heart pumping who are having bypass surgery. It compares two drug combinations (ketamine with lidocaine vs. ketamine with fentanyl) used to put patients to sleep. The goal is to see which combination better keeps blood flo…

This study follows 500 adults with depression, bipolar disorder, or suicide risk who are already receiving care. Researchers will use interviews, questionnaires, and optional tests like blood draws and brain scans to track how symptoms change over time. The goal is to find better…

This study looks back at medical records of critically ill adults in the surgical ICU to compare two common drugs (propofol and ketamine) used when placing a breathing tube. The main goal is to see if one drug is linked to fewer deaths within the first week. Researchers will also…

This study looks at 150 adults having sinus surgery to see how different anesthesia drugs affect brain safety and the surgeon's view. Patients will be randomly assigned to one of four anesthesia combinations. The goal is to find which method best protects the brain and reduces bl…