IBS (IRRITABLE BOWEL SYNDROME)

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet works better than diet alone for easing IBS with diarrhea. About 20 adults aged 18-70 with moderate-to-severe symptoms will join. The goal is to see if the combo improves pa…

This study tests whether low-frequency magnetic pulses aimed at a specific brain area can reduce chronic belly pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will receive either real or sham treatment for two weeks, and researchers will measure chan…

This study tests whether ebastine, an allergy medication, works better than mebeverine (a common IBS drug) at reducing belly pain and other symptoms. About 200 adults with non-constipated irritable bowel syndrome will take one of the two medicines for 12 weeks. The goal is to see…

This study tests a non-invasive belt-like device (Variable Compression System) for people with moderate to severe Irritable Bowel Syndrome (IBS). Twenty participants will wear the device at least 6 hours daily and be followed for 6 months. The goal is to see if it safely reduces …

This study tests whether adding a dietary supplement (NAC) to a standard IBS-D antibiotic (rifaximin) works better than the antibiotic alone. About 225 adults with IBS-D will receive either the combination or a placebo for 4 weeks. The goal is to see if NAC helps break up intesti…

This study tests whether a digestive enzyme blend (FODZYME®) can reduce bloating and stomach pain in adults who often feel bloated. About 150 people will take either the enzyme or a placebo for a period, then switch. The goal is to see if the enzyme helps break down hard-to-diges…

This study tests whether two different blends of a prebiotic (HMO-2FL) and a postbiotic (Humiome® Post LB) can reduce belly pain, bloating, and other gut symptoms in people with Irritable Bowel Syndrome (IBS). About 402 adults with IBS will take one of the two blends or a placebo…

This study tests whether a probiotic called Saccharomyces boulardii can reduce symptoms of irritable bowel syndrome (IBS) in adults who do not have constipation. About 406 participants will receive either the probiotic or a placebo daily for 8 weeks. Researchers will measure chan…

This study looks at the gut microbiome (the collection of bacteria in your digestive system) in people who developed irritable bowel syndrome after an infection. Researchers will compare their gut bacteria to those who had an infection but no IBS, and to healthy people. The goal …

This study looks at people with Irritable Bowel Syndrome (IBS) who have gene variants that reduce their ability to digest starch and sugar. Researchers want to see if these individuals have a smaller rise in blood sugar after a meal and more bowel symptoms compared to those with …